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Berberine can also be used in combination with other drugs such as levetiracetam and curcumin to enhance its neuroprotective effect by reducing inflammation and oxidative stress (Lin et al., 2020

10.1016/j.phymed.2022.154583 67 MasscheleinE.Van ThienenR.DHulstG.HespelP.ThomisM.DeldicqueL

Several hypotheses are being explored: Neuroplasticity effects: Chronic activation of amylin pathways may strengthen neuronal networks that favor satiety over hunger

Yang Y, Yu Q, Zhang C, Wang X, He L, Huang Y, Li E, Qin J, Chen L (2023) Acute thiamethoxam exposure induces hepatotoxicity and neurotoxicity in juvenile Chinese mitten crab ( Eriocheir sinensis )

sadly, many patients develop severe fatal outcomes because of overwhelming inflammation known as cytokine storm (248, 249), that leads to ROS-mediated cell death and tissue damage typical of RNA viruses (250)

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