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Early signs include tingling or 'pins and needles' in the feet and hands, numbness in the extremities, burning pain (often worse at night), balance problems, and muscle weakness
CKD is clinically characterized by a decline in glomerular filtration rate (GFR) and proteinuria for diabetic nephropathy, which is determined by the pathological changes in the structure and function in the kidney of patients with T2DM
Bolaman Z, Kadikoylu G, Yukselen V (2003) Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study
53.0% female and 47.0% male)
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