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However, a significant challenge in evaluating kidney outcomes lies in the inconsistent definitions of renal endpoints across studies, particularly regarding the thresholds for substantial eGFR decline, which vary from 30% to 57%

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By substance there was an 18% reduction in addition to alcohol, 14% for cannabis, 20% for cocaine and nicotine and 25% for opioids compared with an SGLT2 inhibitor

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The possible mechanism affecting the development of tumors is the excessive activation or inhibition of GLP-1R expression