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These include alcohol, opioids, and nicotine (and, anecdotally, online gambling, skin-picking, excessive shopping, and other non-substance related compulsive behaviors)

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Lipid peroxidation occurs during IBD inflammation when ROS are not neutralized, altering the permeability and selectivity of the cell membrane and the activity of transmembrane transporters, receptors, and enzymes (87)

In rare cases individuals inherit a mutation in the GIF gene that encodes intrinsic factor resulting in pernicious anemia