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They are discussed for different reasons, have different research histories, and raise different safety questions

10.3389/fphar.2021.611480 Front Pharmacol

In order to avoid toxicity of cytosolic copper overload, eukaryotes gain control over excess by MTs [177], including the brain-specific MT3 (growth inhibitory factor) binding

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663 While recent discussions have increasingly advocated for the adoption of MAFLD (metabolic dysfunction-associated fatty liver disease) to emphasize the role of metabolic disorders in disease pathogenesis, much of the existing literature has not incorporated this perspective