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HF leads to reduced BA secretion and diminished conversion to secondary BAs, with mechanisms showing marked heterogeneity: certain BAs exert cardioprotective effects through anti-inflammatory and antioxidant pathways, while others may induce cardiac injury at specific dose levels

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In another embodiment, compounds described herein exhibit potent in vitro and in vivo activity against pathogenic cells, such as KB cells, including cisplatin resistant KB cells, NC1/ADR-RES-C1 2 cells, IGROV1 cells, and MDA-MB- 231 cells

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Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production

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