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Setmelanotide, a selective agonist of the MC4R, is approved by the FDA and EMA for the treatment of obesity and control of hunger in Bardet-Biedl Syndrome or biallelic pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency in affected children above age 2 years-old [103]

Nutr Res Pract

Smoothies with protein Helpful when chewing feels like too much work

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For these patients, the goal of personalization is to prescribe just enough medication to achieve targeted results but not so much that the cure feels worse than the disease

4 For patients with an entry A1C of 7.5% or higher, the algorithm recommends dual therapy consisting of metformin plus an additional antihyperglycemic agent