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GLP-1 is an incretin hormone produced by intestinal L-cells that regulates blood glucose, stimulates insulin secretion, and promotes satiety

ongoing investigation into pharmacokinetics

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In women with gestational diabetes, ~200 mg decreased insulin sensitivity by 18% and increased blood sugar by 19%.[68][70] Caffeine also raises cortisol ~50% above baseline, directly raising blood sugar.[71] Iron depletion: One cup of coffee with a meal reduces non-heme iron absorption by 39%