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As part of the inquiry, the MHRA is partnering with Genomics England to explore whether genetic factors may make certain individuals more susceptible to developing pancreatitis while using these medications

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Completion of the trials main phase is expected in September 2025, and the 52-week extension (in which participants and investigators remain blinded to treatment assignment) will continue to October 2026

When to Talk to a Professional If you experience significant pain, swelling, or discoloration at an injection site, its important to contact your healthcare provider

Rybelsus may cause side effects, including nausea, vomiting, diarrhea, and stomach pain

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