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Equally, comprehensive education at therapy initiation shall be provided to patients to inform them about the potential onset of GI AEs and provide with appropriate strategies for their management [15, 64]

Due to insufficient fluid and nutrient uptake, this inadequacy may be further intensified

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The subjective nature of these experiences highlights the importance of personalized treatment approaches and the need for open communication between patients and healthcare providers

Several barriers must be overcome when developing orally administered peptides with a molecular weight above 1,000 Da, including enzymatic degradation in the GI tract, pH-induced conformational changes, limited permeability of the intestinal membrane, and variable GI tract absorption rates [2, 3, 42, 43]

Improved blood sugar control (slower glucose spikes)