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Chronic Gastroparesis & GI Motility Disorders GLP-1 drugs intentionally slow gastric emptying but long-term or high-dose use may lead to persistent or permanent motility impairment

However, starting at a full dose too often causes side effects like bloating, nausea, or constipation

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But the GLP-1 market is getting crowded, and oral alternatives and multiple new injectables are in the pipeline, which could push pricing toward the lower end of that range

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