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As a result, there is currently no data available to assess the clinical implications of GLP-1 RA use in this patient population

A recent perspective article highlighted that semaglutide demonstrated cardiovascular protective effects in individuals with obesity even before significant weight loss, suggesting that GLP-1 RAs may exert cardioprotection through weight-independent mechanisms 33

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Abstract Among the most impactful therapeutic advances in the management of diabetes over the past two decades has been the development of incretin-based therapies, specifically glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) and in combination with glucose-dependent insulinotropic polypeptide (GIP) RAs

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