[55] It suppresses appetite through a dual mechanism: it directly stimulates anorexigenic (satiety-inducing) neurons that express proopiomelanocortin (POMC) and cocaine-and amphetamine-regulated transcript (CART), while simultaneously inhibiting orexigenic (appetite-inducing) neurons that express AgRP and NPY
Niazi notes that GLP-1s can also result in rare but serious side effects, including pancreatitis, gallbladder disease and cholecystitis
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Included in this list are GLP-1 agonists
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Direct Meds GLP-1 has received generally positive feedback, with an average rating of 4.8 out of 5 based on user reviews across platforms like Trustpilot and Reddit discussions