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These so-called non-responders can take massive amounts of supplemental creatine and get no benefit

Weight loss medications typically work by slowing down gastric motility in other words, they reduce how quickly food moves through your stomach

Their activation reduces peristalsis, slows gastric emptying, and alters the migrating motor complex (MMC), which regulates gut motility during fasting periods

When this occurs this metabolic pathway calls upon carnitine within the mitochondria for use in the process and this takes away from the carnitine that is available for fat metabolism

Current Chemical Biology 8(2):89-99. [doi.org]