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Sex differences in NQO1 mRNA expression were observed in the liver of mice on a cafeteria diet

Safety data is limited to the preclinical studies, where no adverse events were reported at therapeutic doses during the 11-week treatment period the longest published study duration

When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig

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