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2025 May;199:115279

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Table 1) Sleep abnormalities Individuals with PWS have sleep-disordered breathing, including central and obstructive sleep apnea, abnormal arousal, abnormal circadian rhythm in REM sleep, reduced REM latency, and abnormal response to hypercapnia 26, 27 as well as excessive daytime sleepiness

Overall, the most significant results are seen over 12 years of consistent treatment, with continued benefits in longer-term follow-up

In addition, ROS function as crucial second messengers, working as redox regulators in a multitude of biological processes ( Glutathione peroxidase (EC 1 -aminobutyrate (GABA) metabolism in Rhizobium leguminosarum 3841 and its role in symbiosis