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But the hard cardiovascular events came in below expectations in both arms, and the MACE analyses, while pre-specified, were not sized to prove event reduction (MACE-5 hazard ratio 0.82, confidence interval crossing 1)

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This mini-review examines the cellular and molecular effects of these agents in children and adolescents, with a focus on key intracellular signaling pathways activated by GLP-1R stimulation, and the potential impacts on cell differentiation, tissue remodeling, bone development, and the gut microbiota