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Janumet (Metformin/Sitagliptin) Janumet 2022 sales: $1.700 billion Company/Developer: Merck Date of first FDA approval: March 30, 2007 Indications Janumet is FDA-approved for: Janumet is a combination of the oral antihyperglycemic drugs sitagliptin and metformin

2040 EORTC item Q168: the psychometric performance of a single-item indicator of side-effect burden for people with cancer Tamara Jones 1 , Florian Zeman 2 , Michael Koller 2 , Andreia Moura 3 , Claire Piccinin 3 , Sandra Nolte 1 1 Person-Centred Research, Eastern Health Clinical School, Monash University, Melbourne, Australia, 2 Center for Clinical Studies, University Hospital Regensburg, Regensburg, Germany, 3 Quality of Life Department, European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2040 Aims Following the release of the US Food and Drug Administration (FDA) Guidance on core patient-reported outcomes in cancer clinical trials, there has been growing interest in using single items to measure treatment tolerability from the patients perspective