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13 When comparing the active GLP-2R structure with the GLP-1-bound GLP-1R structure, 13 the extracellular end of TM1 in GLP-2R is extended by six additional residues, thereby bending toward GLP-2 with the formation of additional hydrogen bond and hydrophobic contacts

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Other than that, SIRT1 promotes threonine phosphorylation, which activates the AMPK signaling pathway and AMPK is known to play a key role in the initiation of adipocyte lipolysis