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In the STEP-1 trial published in The New England Journal of Medicine in 2021, once-weekly subcutaneous semaglutide at 2.4 mg produced a mean placebo-adjusted body weight reduction of 12.4% at 68 weeks in adults with overweight or obesity (Wilding et al., NEJM, 2021)

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In the liver statins inhibit HGM-CoA resulting in downregulation of the mevalonate pathway and increases in LDLR expression and LDL-C concentrations

3.3.2 The comparison of urinary AKI biomarkers between two groups According to statistical results, it showed that mean SD of NGAL after treatment were 138.4 82.3, 107.6 42.0 in RG group and RG + CHF group respectively

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