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Standard prokinetics bypass this entirely by directly stimulating gastric smooth muscle or dopamine receptors

GLP-1 medications change how your body handles hunger, digestion, and cravings in ways that make your old eating habits risky in ways that sneak up on you

For patients with unusual weight (such as morbid obesity), it may be helpful to check a phenobarbital level 2 hours after the initial loading dose (to confirm an adequate level was achieved and to calculate V D )

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BMI 40.0 and above (class III obesity)

This ensures the full dose delivers into the subcutaneous tissue and prevents medication from leaking back out through the injection site