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Hallmark gene set analysis reveals pathways associated with interferon-alpha responses and DNA damage repair are downregulated while pathways associated with sterile inflammation are upregulated in NHBECs after DA vapor exposure To further characterize transcriptional profiles, we applied the pre-ranked GSEA to 50 Hallmark gene sets with well-defined biological mechanisms and coherent expression levels

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Inflammation 38(6):22792287 Sithu SD, Srivastava S, Siddiqui MA, Vladykovskaya E, Riggs DW, Conklin DJ et al (2010) Exposure to acrolein by inhalation causes platelet activation