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Over the next decades, this has prompted several modifications to make ADT increasingly more complete and potent in inhibiting AR, which have been the subject of excellent reviews [4, 7, 8]

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[33] Methods of assessment [edit] An increase in prothrombin time, a coagulation assay, has been used as an indicator of vitamin K status, but it lacks sufficient sensitivity and specificity for this application

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More rarely, a patient may experience severe symptoms such as a fever of 100.4F (38C) or higher, injection site blistering, muscle pain, skin rashes, hives, severe skin itching, or vomiting