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Folic acid supplementation can alleviate the symptoms of anemia in patients with dihydrofolate reductase deficiency, but this does not correct the deficiency of tetrahydrofolate in the brain, often leaving neurological sequelae
This is also due to the direct proximity of immune cells, located under the layer of intestinal epithelial cells [1, 2]
doi: 10.1126/science.1100747
Laboratory Tests For the diagnosis of pernicious anemia, the following laboratory tests are frequently used
intracellular half-life is prolonged because of lysosomal release and cytosolic resequestration, creating a depot effect that supports monthly maintenance dosing for chronic deficiencies