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10.1111/bph.12459 56 SosneG.KleinmanH

doi:10.1186/s12876-021-01707-7 74

Hypoglycemia: Low blood sugar is more common when taking a GLP-1 with insulin or a sulfonylurea

Currently available GLP-1 receptor agonists in the UK include: Exenatide (short-acting and extended-release formulations) - licensed for type 2 diabetes Liraglutide (once-daily injection) - licensed for type 2 diabetes (Victoza) and separately for weight management (Saxenda 3mg) Dulaglutide (once-weekly injection) - licensed for type 2 diabetes, including cardiovascular risk reduction in those with established cardiovascular disease or multiple risk factors Semaglutide (once-weekly injection and oral formulation) - licensed for type 2 diabetes (Ozempic, Rybelsus) and separately for weight management (Wegovy 2.4mg) A related but distinct medication is tirzepatide (once-weekly injection), which is a dual GIP/GLP-1 receptor agonist licensed for type 2 diabetes management

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Cost and insurance-related barriers are the most common reasons people stop taking GLP-1s, according to research by Gasoyan's team