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Recently, it has been demonstrated that mice with a deletion of the GLP-1 receptor only in -cells, are resistant to the beneficial anti-diabetic effect of a vertical sleeve-gastrectomy ( It appears that only in RYGB and SG patients intestinal derived GLP-1 has a true endocrine role, while in healthy individuals, localized, paracrine and neuronal signals primarily define the GLP-1 physiology

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Time-series profiling of injured muscle revealed stage-specific transcriptional waves, ranging from early inflammatory and immune activation to mid-phase myogenic and extracellular matrix (ECM)-remodeling gene expression and late-phase tissue maturation

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Stopping usually leads to gradual weight regain, which is why we treat Contrave as ongoing therapy, not a short course