SP@M increases LC3-mediated autophagy as well as strengthens ubiquitin-mediated proteasomal degradation toward KEAP1, which promotes the expression and nuclear translocation of NRF2
Balasubramanian, K
This does not usually work for a few reasons
Stephenson CM, Levin RD, Spector T, Lis CG
Authors concluded that combining NRT with behaviour change counselling resulted in a significantly higher quit rates and lower cotinine levels, but significant impact on patient-related or microbiological outcomes were not detected (Sharma et al., 2018)
I made that decision mainly based on the data that I'm aware of, looking at comparison of people doing that anywhere from two to four grams of EPA per day, compared to SSRIs, selective serotonin reuptake inhibitors and treatment of depression