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In addition, mTORC1 promotes nucleotide synthesis by stimulating the mTHF cycle, which increases ATF4 levels to upregulate the expression of methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) [45]

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However, once the benzimidazole is detached from cobalt by quaternization with methyl iodide, it is replaced by H 2 O or hydroxyl ions

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