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It appeared that sulofenur can undergo metabolic biotransformation to yield the GSH-conjugate of p -chlorophenyl isocyanate [ S -( N - p -chlorophenylcarbamoyl) GSH, SCPG

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The first ADC for treatment of solid tumors was Ado-Trastuzumab Emtansine (Kadcyla ) or T-DM1 for treatment of HER2+ metastatic or locally advanced breast cancer and was approved in 2013 (162)

Gclc L-KO mice showed no overt histological signs of liver damage (Fig