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In patients on total parenteral nutrition, approximately 12 to 15 mM of phosphorus (equivalent to 372 to 465 mg elemental phosphorus) per liter bottle of TPN solution containing 250 g dextrose is usually adequate to maintain normal serum phosphorus, though larger amounts may be required in hypermetabolic states

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In some embodiments, the otoprotectant is Sodium Thiosulfate

Hao, Y., Xing, M., & Gu, X