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These medications fundamentally alter pancreatic islet cell function in a glucose-dependent manner, which provides both therapeutic efficacy and an important safety advantage over older diabetes medications

Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat)

Ivanov D, Mazzoccoli G, Anderson G, et al

In addition to those with type 2 diabetes, other people may benefit from metformin

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