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Micronutrient and nutritional deficiencies associated with GLP-1 receptor agonist therapy: a narrative review

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Haemorrhoidal disease is seen in all age groups from the mid-teens onwards, with incidence tending to increase with age, until the seventh decade of life

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Semaglutide works by stimulating the pancreatic beta cells to produce more insulin, improving glucose tolerance

It shares 94% sequence homology with human GLP-1 but has been structurally modified to resist rapid enzymatic breakdown, giving it a significantly extended half-life compared to native GLP-1