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In parallel, ACE-mediated hydrolysis of Ac-SDKP is studied using biochemical kinetics and structural characterization approaches, providing a mechanistic basis for interpreting Ac-SDKP availability in experimental systems

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The histone 3 lysine 27 acetylation (H3K27ac) activity at regulatory elements such as enhancers and promoters, that is mediated by the acetyl transferases CBP and p300 is required for cell type-specific gene expression patterns

doi: 10.1002/edm2.163 64