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Tirzepatide engages two separate hormone pathways simultaneously: GLP-1 and GIP receptors

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In addition, central nervous system OXT receptors also are distributed in the pancreas, adipocytes, anterior pituitary gland, vagus nerve and gastrointestinal tract [108]

When engineered as spacers, they can physically separate the cervix from adjacent radiosensitive organs such as the bladder and rectum, thereby permitting safe dose escalation during brachytherapy [73]

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