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Within skeletal muscle, release of Ca 2+ from the SR and subsequent binding of Ca 2+ to troponin C is required to induce muscle contraction

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281 showed capability of rGO to activate hydrogen peroxide through a Fenton-like pathway, generating hydroxyl radicals (OH) that mediate the selective hydroxylation of benzene to phenol, shown in Fig

The methyl donor for this reaction is S-adenosylmethionine (SAM or AdoMet) and the reaction is catalyzed by the enzyme guanidinoacetate N -methyltransferase