nrf2 glutathione synthesis Dynamic modeling of pathway activation in liver cells after toxicant exposure NRF2 plays a critical role – NRF2, a Transcription Factor for

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J Apic Res

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10.1111/jcmm.15904 132 NiZ.TaoL.XiaohuiX.ZelinZ.JiangangL.ZhaoS.et al (2017)

These observations highlight the suitability of the HepG2 model to study these events and the necessity to define cellular sensors and signaling cascades involved in the NFT-induced increase of glutathione levels

This allows it to penetrate deep into the mitochondria and even cross the blood-brain barrier