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Search strategy and data extraction PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were systematically searched from inception to February 23, 2024, with the following search terms: Retatrutide OR LY3437943

We got an early start on a hot Friday morning in July

As a tryptophan catabolite produced by the intestinal microbiota, indole is an indispensable signaling molecule regulating intestinal homeostasis (Roager and Licht, 2018)

Of note, lorcaserin, which was previously approved for long-term obesity management, was withdrawn from the market in 2020 for a safety issue related to increased cancer incidence [22]