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Following intravenous administration, SEM plasma concentrations exhibited a multi-exponential decline, with an average half-life (T1/2) of 9.26 1.06 h and an average clearance and distribution volume estimated at 0.21 mL/min/kg (0.10 L/kg) [58]

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Twenty-fourhour ambulatory BP was monitored and recorded in a representative subgroup of consenting patients by TM-2430 equipment (A&D Company, Tokyo, Japan) that was set to obtain measurements at 15-minute intervals during daytime (6:00 am to 10:00 pm) and 30-minute intervals during nighttime (10:00 pm to 6:00 am)