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10.1016/j.cell.2012.03.042 27 DixonS

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5.2.4 Ferroptosis suppressor protein 1 and coenzyme Q10 pathway FSP1 possesses NAD(P)H oxidoreductase activity and reduces CoQ to ubiquinol (CoQH2), which inhibits lipid peroxidation and ferroptosis by trapping lipid peroxidation free radicals (77, 78)

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Certain symptoms require escalation , including severe or worsening pain, progressive weakness, or changes in bowel or bladder function