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Likewise, defining the critical pathogenetic mediators of the process might provide new and more specific therapeutic targets for various ferroptosis-related diseases

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The process is not limited to insulin, since other molecules such as bovine serum albumin and hGH are taken up in the same way

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In these reactions, -KG is oxidized to succinate, and increasing levels of succinate can suppress the progression of -KG-dependent histone or DNA demethylase reactions 98

Inhibition of ASK1 has therefore been proposed as a target for the treatment of NASH