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Weaning off tirzepatide requires gradual dose reduction, not abrupt cessation

The effect on bones, for instance, is being examined

The stock has plummeted 83% this year on concerns about the company's debt load, its core weight loss business and Oprah Winfrey's announced departure from the board in February

Heres how it complicates weight management: Slower metabolism Thyroid hormones help regulate your basal metabolic rate the number of calories your body burns at rest

Central appetite regulation Semaglutide crosses the blood-brain barrier and activates GLP-1 receptors in multiple brain regions involved in appetite regulation

Once hailed primarily for managing type 2 diabetes and chronic weight loss, these therapies are now reshaping cardiometabolic care with broader clinical impact and improved patient access