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Activation- independent carcinogens, or "direct-acting" carcinogens, are those that are capable of directly damaging DNA without any modification to their molecular structure

Large et al

Finally, consider the nicotine strengths you are using

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Smoke from cigarettes and other smoked tobacco products releases toxic chemicals into the air, causing undue harm to the environment and people

"Scientific Opinion on Safety of smoke flavour Primary Product AM 01"