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In clinical trials, lower doses of Ozempic resulted in a mean increase in heart rate of two to three beats per minute. Some patients have found the experience uncomfortable

Rodent studies demonstrated an increased incidence of thyroid C-cell tumors (medullary thyroid carcinoma) at doses proportionally higher than those used in humans

The effects of various dosing schedules on the pharmacokinetics of oral semaglutide was investigated [68]

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With proper management of reflux symptoms, many patients can safely use semaglutide over the long term