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Since creatine synthesis is responsible for most of the methyl group transfers that result in Hcy formation, creatine supplementation might inhibit Hcy production and reduce free radical formation

Dietary modifications, dose reduction, or slower titration may improve tolerability whilst maintaining therapeutic benefit

Fogg-Johnson N and Kaput J

Given these benefits, its easy to see why many people consider omega-3 supplementation as part of their daily routine

Research from the Baker Institute in Melbourne has demonstrated these epigenetic changes in POTS patients (Khan et al., Neuroscience and Biobehavioral Reviews , 2017

Expected FDA decision Q3 2026