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The other family members more than likely evolved from PLC- as their domain architecture and mechanism of activation were expanded

10.1155/2017/6274854 [DOI] [PMC free article] [PubMed] [Google Scholar] 29.Askarpour M, Hadi A, Dehghani Kari Bozorg A, Sadeghi O, Sheikhi A, Kazemi M, et al

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In the United States, the Food and Drug Administration (FDA) classified BPC-157 as Category 2 for compounding due to adverse immune system reactions, peptide-related impurities and insufficient safety information to determine whether it would cause harm when administered to humans