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Data availability Data are available on request from the authors at sequent email addresses: Mauro Pettorruso, MD, PhD

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It exerts its effects through two primary pathways: direct binding to the GH receptor (GHR) on target tissues producing immediate metabolic effects including lipolysis, insulin antagonism, and protein synthesis and indirect stimulation of IGF-1 production in the liver and peripheral tissues, which mediates the majority of GHs anabolic and growth-promoting effects

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Prescribers refer to it as the drug of last resort

GHK-Cu is explored in extracellular-matrix and dermal studies