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Data availability Quantitative raw data can be provided by Laurent Gautron as Prism files upon request

Those who switched from tirzepatide to orforglipron regained about 11 pounds of the weight they lost on average over a year (almost 55 pounds total)

J Nucl Med 38(6):925928 Jamshed H, Beyl RA, Della MD, Yang ES, Ravussin E, Peterson CM (2019) Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

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Oral supplement users typically report 8 to 12 weeks for visible changes

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