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Trials without explicit quantitative thresholds were classified by qualitative descriptors (e.g., T2D diagnosis required, Liver disease excluded, Not specified)

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Summary of Critical Appraisal The included study 13 achieved randomization using an interactive web response system, limiting the possibility that randomization was inadequate

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It acts as a cofactor for methionine synthase and methylmalonyl-CoA mutase, enzymes that are critical for one-carbon metabolism as well as the catabolism of odd-chain fatty acids and branched-chain amino acids (Rucker et al., 2007)