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Forty-four RCTs were selected from a systematic review conducted by Lancaster et al.167, 268, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336 In addition, seven more recent RCTs were identified in an updated search,337, 338, 339, 340, 341, 342, 343 yielding a total of 51 RCTs included for data synthesis

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LD50 values) have considerable uncertainty (for example, more than a factor of 10 for diazepam in different species)

Yes, the damage done can't be reversed, but the risks can easily be reduced to a nominal level.

They recognized their own fears in her red book