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2-hydroxynicotinic acid (2-OHNA) inhibits NAPRT by binding to its active site, preventing the conversion of NA to NAD +

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Another randomized controlled trial showed that soybean isoflavone therapy (80 mg/day, P.O for 24 weeks) significantly increased the protein and mRNA levels of Nrf2 and the concentrations of SOD as well as diminished serum levels of inflammatory factors and MAD in patients with myocardial ischemia [139]

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